public beta · research use only

EVIDENCE. IN THE OPEN.

An open hub for AI-generated peptide candidates. Every sequence gets a card. Every card ships with a recipe. Every fork is traceable.

cards 1739
targets 64
authors 1
reproduced 223

PeptideModel is an open research database for AI-generated peptide candidates. Every entry follows a five-level evidence pipeline — designed, computed, reproduced, synthesized, and bioassayed — that distinguishes AI proposals from experimentally validated sequences. Each card records the full prediction recipe (model, version, hardware, seeds, command) for independent reproducibility. All data is CC-BY-SA 4.0 and accessible via a free public API at api.peptidemodel.com. The platform currently indexes 1739 sequences across 64 biological targets.

Semaglutide FLAGSHIP weight loss & type-2 diabetes BPC-157 FLAGSHIP gut healing & tissue repair DF-3 ADVANCED muscle growth GIP (1-30) FLAGSHIP insulin release, obesity treatment Melanotan I FLAGSHIP skin darkening & sun-pain protection Tirzepatide ADVANCED weight loss & type-2 diabetes Retatrutide FLAGSHIP weight loss & metabolism Cagrilintide FLAGSHIP appetite suppression & weight loss Oxytocin ADVANCED labor & social bonding Elamipretide FLAGSHIP stabilizes cellular energy production Setmelanotide ADVANCED genetic obesity treatment Sermorelin ADVANCED stimulates growth hormone release LL-37 ADVANCED kills bacteria & pathogens MOTS-c ADVANCED energy metabolism & longevity Vasopressin ADVANCED water retention & blood pressure Gramicidin D ADVANCED kills gram-positive bacteria Semaglutide FLAGSHIP weight loss & type-2 diabetes BPC-157 FLAGSHIP gut healing & tissue repair DF-3 ADVANCED muscle growth GIP (1-30) FLAGSHIP insulin release, obesity treatment Melanotan I FLAGSHIP skin darkening & sun-pain protection Tirzepatide ADVANCED weight loss & type-2 diabetes Retatrutide FLAGSHIP weight loss & metabolism Cagrilintide FLAGSHIP appetite suppression & weight loss Oxytocin ADVANCED labor & social bonding Elamipretide FLAGSHIP stabilizes cellular energy production Setmelanotide ADVANCED genetic obesity treatment Sermorelin ADVANCED stimulates growth hormone release LL-37 ADVANCED kills bacteria & pathogens MOTS-c ADVANCED energy metabolism & longevity Vasopressin ADVANCED water retention & blood pressure Gramicidin D ADVANCED kills gram-positive bacteria

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A designed ring peptide switched on the BDNF receptor and grew axons in a dish
BDNF makes a terrible drug. A screening system built a rigid macrocyclic peptide that grips TrkB, then two copies were fused so the molecule clamps a pair of receptors and switches them on. It fired TrkB, lit ERK and AKT, and elongated axons in cultured neurons. No animal, no dosing, no disease model yet.
NEUROPROTECTIVE
GLP-1 drugs cut weight and insulin in type 1 diabetes, not time in range
Eighteen reviews say GLP-1 drugs help in type 1 diabetes. A new overlap-informed umbrella review shows they re-pool the same few trials. Weight fell about 3.9 kg and insulin dropped, but time in range did not move, and the most certain findings were nausea, vomiting, and dropouts.
GLP-1R
A designed peptide gripped an undruggable cell-division protein and stalled liver cancer in mice
Peptide-4 binds Ndc80, half of the clamp that dividing cells use to grab spindle fibers, at 0.45 nanomolar and blocks its partnership with Nuf2. In liver-cancer cells it forced mitotic arrest and death, and it slowed tumors in mice. The target is a flat protein interface small molecules cannot hold, and the whole story is still preclinical.
ANTICANCER

browse by target · 53 targets indexed

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The grid of family cards becomes a body-map on-ramp. Pick a system — by tab, by the figure, or by the index — and the panel resolves to that region's targets, ranked by activity, one click from the full list.

view anterior · male · icon-led systems · mapped rig

how it works · platform pipeline · all cards

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1designed
1,739100.0%
2computed
1,71298.4%
3reproduced
42224.3%
4synthesized
42124.2%
5bioassayed
25414.6%

Every card carries a five-level status. Anyone can design; computation and reproduction require a recipe and attached artifacts; synthesis requires an LC-MS spectrum; assay requires a protocol and raw data. The funnel is steep because the schema is strict — and that's the point.

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