public beta · research use only

EVIDENCE. IN THE OPEN.

An open hub for AI-generated peptide candidates. Every sequence gets a card. Every card ships with a recipe. Every fork is traceable.

cards 1742
targets 62
authors 1
reproduced 224

PeptideModel is an open research database for AI-generated peptide candidates. Every entry follows a five-level evidence pipeline — designed, computed, reproduced, synthesized, and bioassayed — that distinguishes AI proposals from experimentally validated sequences. Each card records the full prediction recipe (model, version, hardware, seeds, command) for independent reproducibility. All data is CC-BY-SA 4.0 and accessible via a free public API at api.peptidemodel.com. The platform currently indexes 1742 sequences across 62 biological targets.

BRP (BRINP2-Related Peptide) NEW Semaglutide FLAGSHIP GLP-1R BPC-157 FLAGSHIP tissue repair DF-3 ADVANCED reproduced · 3D model Tirzepatide FLAGSHIP gipr Melanotan I FLAGSHIP mc1r Oxytocin ADVANCED bioassayed · 3D model Retatrutide FLAGSHIP gcgr Cagrilintide FLAGSHIP calcr Sermorelin ADVANCED bioassayed · 3D model Elamipretide FLAGSHIP cardiolipin LL-37 ADVANCED bioassayed · 3D model MOTS-c ADVANCED bioassayed · 3D model Gramicidin D ADVANCED bioassayed · 3D model Vasopressin ADVANCED bioassayed · 3D model IGF-1 LR3 ADVANCED bioassayed · 3D model GHRP-2 ADVANCED bioassayed · 3D model BRP (BRINP2-Related Peptide) NEW Semaglutide FLAGSHIP GLP-1R BPC-157 FLAGSHIP tissue repair DF-3 ADVANCED reproduced · 3D model Tirzepatide FLAGSHIP gipr Melanotan I FLAGSHIP mc1r Oxytocin ADVANCED bioassayed · 3D model Retatrutide FLAGSHIP gcgr Cagrilintide FLAGSHIP calcr Sermorelin ADVANCED bioassayed · 3D model Elamipretide FLAGSHIP cardiolipin LL-37 ADVANCED bioassayed · 3D model MOTS-c ADVANCED bioassayed · 3D model Gramicidin D ADVANCED bioassayed · 3D model Vasopressin ADVANCED bioassayed · 3D model IGF-1 LR3 ADVANCED bioassayed · 3D model GHRP-2 ADVANCED bioassayed · 3D model

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browse by target · 62 targets indexed

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secretin receptor family (class B GPCR)
GLP-1R
GLP-1 receptor
cards229
authors1
regenerative
Tissue Repair
wound healing
cards5
authors1
TGF-β superfamily
GDF-8
myostatin
cards3
authors1
best0.742
rhodopsin-like GPCR (class A)
GHSR
ghrelin receptor
cards21
authors1
neuroactive
Neuroprotective
nootropic
cards8
authors1
rhodopsin-like GPCR (class A)
MC1R
melanocortin-1 receptor
cards4
authors1
Longevity
cards7
authors1
rhodopsin-like GPCR (class A)
OPRM1
mu-opioid receptor
cards33
authors1
best4

how it works · platform pipeline · all cards

read the protocol →
1designed
1,742100.0%
2computed
1,780102.2%
3reproduced
24514.1%
4synthesized
24514.1%
5bioassayed
25414.6%

Every card carries a five-level status. Anyone can design; computation and reproduction require a recipe and attached artifacts; synthesis requires an LC-MS spectrum; assay requires a protocol and raw data. The funnel is steep because the schema is strict — and that's the point.

latest news · original reporting

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MHP1-AcN, a RANKL-derived peptide first developed for bone biology, binds LGR4 directly and displaces the IQGAP1 scaffold that R-spondin-3 needs to potentiate Wnt signaling. In Anticancer Research, daily intraperitoneal dosing shrank A549 lung adenocarcinoma xenografts in BALB/c nude mice and reduced LRP6 phosphorylation, beta-catenin accumulation, and migration in dish.
ANTICANCER 4 min read
CIP-3, an AI-designed cyclic peptide reported May 30 in Advanced Science, binds CD28 at nanomolar affinity with no intrinsic agonist activity, suppresses T-cell activation in primary human cells, and matches a benchmark anti-CD28 biologic on cytokines in ulcerative colitis PBMCs. The kinetic profile is the part biologics do not have: occupancy tracks exposure rather than persisting for days.
IMMUNE 4 min read
PEG0, PEG3, PEG7, and PEG11 chelator-peptide linkers were scanned for an αvβ6 integrin theranostic. Affinity sat at 0.2 to 0.5 nM across all four; the PEG7 trimer led on tumor uptake at 24 h, ran 65 to 671 fold over other integrin subtypes, and held a 6-day SPECT retention curve in mice.
ANTICANCER 4 min read

recent activity · live feed across all targets

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