Dulaglutide didn't slow nerve damage in a small MS trial
A year of weekly GLP-1 on top of standard MS treatment dropped weight, fat, and glucose but left the two nerve-damage markers it was built to move completely flat.
Peptide research, regulation, discovery. Every story links to the peptide it’s about.
RSSA year of weekly GLP-1 on top of standard MS treatment dropped weight, fat, and glucose but left the two nerve-damage markers it was built to move completely flat.
The EMA's first dedicated guideline for synthetic peptide active substances took legal effect on June 1, setting manufacturing and impurity-control standards for the chemistry behind drugs like Wegovy and Mounjaro. It lands as France becomes the first EU country to reimburse them.
In an 878-patient substudy of the GLORIOUS trial, a continuous exenatide infusion during cardiopulmonary bypass left three-month lung function no better than placebo. Both groups lost about 7.7 points of diffusing capacity, and the drug groups did not separate.
In a single-center cohort of 41 children with short bowel syndrome, the GLP-2 peptide teduglutide got 21 (about half) off intravenous nutrition entirely, with a median 7.3 months to wean. Response tracked residual bowel length.
A deep-learning model screened 19.3 million fragments cut from prion proteins and flagged 1,179 antibiotic candidates. Of 75 the Penn team synthesized, 59 killed bacteria and two cleared infections in mice.
The first pooled analysis of the CNP analogs vosoritide and navepegritide found about 1.36 cm a year of extra growth in children with achondroplasia, but no change in the body-proportion ratio that defines the condition.
German researchers rebuilt the cell-death protein BNIP3 into B-017, an antagonist peptide that kept the mitochondrial self-destruct switched off and reduced damage in the heart, brain, and liver of animals.
A prospective study of 320 IVF cycles found the same hormone pointing opposite ways: higher oxytocin in the blood meant lower odds of a live birth, while higher oxytocin in the fluid around the egg meant better odds. The compartment, not the molecule, changed the sign.
A single injection of MID-35, a mirror-image myostatin blocker, enlarged mouse leg muscle for three months. The fat-signal it leaned on to wake muscle stem cells rose in young and adult mice but never showed up in aged ones, the muscle a real drug would target.
In a 17-child phase II study, a WT1 peptide vaccine given as post-transplant maintenance reached 70.6 percent three-year survival, and the children whose killer T cells actually responded survived far better than those whose did not.
A target trial emulation in All of Us found adults who started semaglutide were about half as likely to develop a new seizure disorder, and the benefit ran through neither glucose control nor weight loss.
A chimeric peptide stitches a glioblastoma-homing sequence to a 7-amino-acid fragment of the dengue virus, then carries gallium-67 or lutetium-177 across the blood-brain barrier. In cells and healthy mice it works, but brain uptake is low and no tumor has been treated yet.
A JAMA Viewpoint counts 130,000 Instagram posts and 230 million TikTok views for injectable peptides like BPC-157 and TB-500, and warns the safety research and rules have not caught up. The FDA weighs seven of them for legal compounding on July 23.
A Nature Nanotechnology team used a modified bacterial pore to tell all 20 amino acids apart, read peptides up to 39 residues long, and reconstruct a peptide's sequence from overlapping fragments at up to 97.4 percent accuracy, clearing the obstacle that has kept protein nanopore sequencing stuck for years.
A meta-analysis of 12 trials and 91,167 patients found GLP-1 receptor agonists reduced major heart events and cardiovascular death by about a fifth in people with a BMI under 30, the same size of benefit seen in obese patients, with no sign the effect depends on starting weight.