CATEGORY · MULTI-MECHANISM

Longevity

aging

Peptides targeting telomerase activation, mitochondrial function, or AMPK signaling associated with aging and cellular longevity.

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What is a category target?

Groups peptides by what they do, not what they bind. There's no PDB or UniProt — the target is a function, not a molecule. For receptor-level structure, open a molecular target like GHSR.

anchor card · canonical reference for this target

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MOTS-c: natural mitochondrial peptide tied to metabolism and longevity

MRWQEMGYIFYPRKLR · 16 aa · @peptidemodel

bioassayed pep-00003 @peptidemodel refs: 5

all cards · 7 candidates against Longevity

# id title author status refs metric
1 pep-10960 Adropin: heart and metabolism hormone linked to energy balance (ENHO peptide) pe@peptidemodel
1 0
2 pep-10934 Vesugen (KED): blood-vessel health peptide pe@peptidemodel
1 0
3 pep-10779 Brain-protective research peptide (SALLRSIPA) pe@peptidemodel
8 0
4 pep-10778 Davunetide: brain-protecting peptide (NAPVSIPQ) pe@peptidemodel
6 0
5 pep-10776 Humanin: natural cell-protection signal made by mitochondria pe@peptidemodel
5 0
7 pep-00008 Epithalon: experimental longevity peptide (Epitalon / AEDG) pe@peptidemodel
13 0
1–7 of 7

target literature · 38 curated papers

[1]
Zhu, Dan et al. 2012 Cell Metabolism Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth
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[2]
Khavinson, Vladimir et al. 2020 Molecules Peptides: Prospects for Use in the Treatment of COVID-19
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[3]
Brenneman, D. et al. 1996 Journal of Clinical Investigation A femtomolar-acting neuroprotective peptide.
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[4]
Mongkolnkrajang, U. et al. 2026 Scientific Reports Bee pollen-derived peptide with dual DPP-IV Inhibition and glucose transport modulation
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[5]
Bakhshinejad, B. et al. 2025 Frontiers in Microbiology On the origin of non-specific binders isolated in the selection of phage display peptide libraries
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[6]
Saitoh, M. et al. 2021 Bioorganic & Medicinal Chemistry Letters Strategic structure–activity relationship study on a follistatin-derived myostatin inhibitory peptide
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1
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[9]
Mavrych, V. et al. 2026 Frontiers in Aging Therapeutic peptides in gerontology: mechanisms and applications for healthy aging
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