Mitochondrial-derived peptides (MDPs) are encoded in the mitochondrial genome and act as retrograde signaling molecules. MOTS-c (16 aa) activates AMPK and regulates metabolic homeostasis - it was the first MDP shown to have systemic metabolic effects (Lee et al. 2015, Cell Metabolism).
MDPs represent a new class of endogenous peptide hormones. Their mitochondrial origin means they evolve under different selective pressures than nuclear-encoded peptides, making them interesting targets for sequence optimization.
Groups peptides by what they do, not what they bind. There's no PDB or UniProt — the target is a function, not a molecule. For receptor-level structure, open a molecular target like GHSR.
MRWQEMGYIFYPRKLR · 16 aa · @peptidemodel
| # | id | title | author | status | refs | ipSAE_d0chn | ♥ |
|---|---|---|---|---|---|---|---|
| 1 | pep-00003 | MOTS-c: natural mitochondrial peptide tied to metabolism and longevity | pe@peptidemodel | 5 | — | 0 |
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