pep-10540 v1 CC-BY-SA-4.0
Bone-research blocker of parathyroid hormone action ((Tyr34)-pTH (7-34) amide, bovine)
A lab-made fragment of parathyroid hormone that blocks the hormone's own receptor, used in animal studies to understand how bones form and grow. Research tool only, not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.827
pTM0.609
avg pLDDT42.3
ranking score0.944
STRUCTURE · PEP-10540 × PTH1R
ranking0.944
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202528
FMHNLGKHLSSMER VEWLRKKLQDVHNY
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.8272114992141724 | openfold3-mlx |
| ranking score | 0.9437122941017151 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.952 | global PDE — lower = better |
| disorder | 0.320 | ! high disorder |
| chain pair ipTM (A, B) | 0.827 | interface quality |
▸3-letter notation
Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| diffusion samples | 1 |
| runtime | 776s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
python3 openfold3/run_openfold.py predict --query_json {query.json} --runner_yaml examples/example_runner_yamls/mlx_runner.yml --output_dir {output_dir} --num_diffusion_samples 1 ▸citationbibtex
peptidemodel (2026). Bone-research blocker of parathyroid hormone action ((Tyr34)-pTH (7-34) amide, bovine) (pep-10540, v1). PeptideModel. https://peptidemodel.com/card/pep-10540
@peptide{pep10540,
sequence = {FMHNLGKHLSSMERVEWLRKKLQDVHNY},
target = {pth1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
clinical trials
0
no registered clinical trials
as of 2026-05-22; we'll re-check periodically
references
discussion
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