pep-10439 v1 CC-BY-SA-4.0
Bone-signaling peptide (CHEMBL1276263)
A small experimental peptide that switches on the body's main receiver for parathyroid hormone, the signal that controls calcium levels and bone health. Experimental, not yet an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.912
pTM0.805
avg pLDDT60.6
ranking score0.667
STRUCTURE · PEP-10439 × PTH1R
ranking0.667
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
157
VEIKLHE
in the news
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| EC50 | 1122 nM | GPCRDB/ChEMBL |
▸3-letter notation
Val-Glu-Ile-Lys-Leu-His-Glu
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | colabfold_local |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-22 |
▸citationbibtex
peptidemodel (2026). Bone-signaling peptide (CHEMBL1276263) (pep-10439, v1). PeptideModel. https://peptidemodel.com/card/pep-10439
@peptide{pep10439,
sequence = {VEIKLHE},
target = {pth1r},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
clinical trials
0
no registered clinical trials
as of 2026-05-22; we'll re-check periodically
references
discussion
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