pep-05475 v1 CC-BY-SA-4.0
Alpha-synuclein antimicrobial peptide
A naturally occurring antimicrobial peptide that kills or slows the growth of bacteria; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.000
pTM0.581
avg pLDDT83.0
ranking score0.780
STRUCTURE · PEP-05475 × ANTIMICROBIAL
ranking0.780
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530354045505560
MDVFMKGLSKAKEGVVAAAE KTKQGVAEAAGKTKEGVLYV GSKTKEGVVHGVATVAEKTK
in the news
Prions are known for misfolding. An AI found antibiotics inside them. ANTIMICROBIAL · via ANTIMICROBIAL
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| ranking score | 0.780462920665741 | boltz-2 |
▸3-letter notation
Met-Asp-Val-Phe-Met-Lys-Gly-Leu-Ser-Lys-Ala-Lys-Glu-Gly-Val-Val-Ala-Ala-Ala-Glu-Lys-Thr-Lys-Gln-Gly-Val-Ala-Glu-Ala-Ala-Gly-Lys-Thr-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-Glu-Gly-Val-Val-His-Gly-Val-Ala-Thr-Val-Ala-Glu-Lys-Thr-Lys
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | none_monomer |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-23 |
▸citationbibtex
peptidemodel (2026). Alpha-synuclein antimicrobial peptide (pep-05475, v1). PeptideModel. https://peptidemodel.com/card/pep-05475
@peptide{pep05475,
sequence = {MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK},
target = {antimicrobial},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
sign in to comment