CATEGORY · MULTI-MECHANISM

Skin Peptides

cosmeceutical
dermatological and cosmeceutical peptides
skin

Cosmeceutical peptides target skin aging, pigmentation, and barrier function. Argireline (acetyl hexapeptide-3, EEMQRR) inhibits SNARE complex assembly to reduce muscle contraction - a topical alternative to botulinum toxin. Decapeptide-12 (YRSRKYSSWY) is a patented tyrosinase inhibitor for skin lightening.

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a tripeptide that stimulates collagen synthesis and wound healing. The peptide sequence GHK is the minimal active unit; copper chelation enhances activity.

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What is a category target?

Groups peptides by what they do, not what they bind. There's no PDB or UniProt — the target is a function, not a molecule. For receptor-level structure, open a molecular target like GHSR.

anchor card · canonical reference for this target

anchor

Argireline: topical anti-wrinkle cosmetic peptide (acetyl hexapeptide-3)

EEMQRR · 6 aa · @peptidemodel

bioassayed pep-00014 @peptidemodel refs: 2

all cards · 3 candidates against Skin Peptides

# id title author status refs ipSAE_d0chn
1 pep-00009 GHK: natural skin-repair peptide (copper-binding, found in human blood) pe@peptidemodel
3 0
2 pep-00014 Argireline: topical anti-wrinkle cosmetic peptide (acetyl hexapeptide-3) pe@peptidemodel
2 0
3 pep-00015 Decapeptide-12: Lumixyl skin-brightening peptide pe@peptidemodel
1 0
1–3 of 3

target literature · 6 curated papers

[2]
Pickart, L. et al. 2012 BioMed Research International GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration
cited by
1
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[4]
Blanes-Mira, C. et al. 2002 Int J Biol Macromol A synthetic hexapeptide (Argireline) with antiwrinkle activity
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1
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[5]
Wisniewski, J.D. et al. 2014 International Journal of Cosmetic Science The efficacy of Argireline in reducing wrinkle depth
cited by
1
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