pep-05443 v1 CC-BY-SA-4.0
Viral envelope gp160 HIV-blocking peptide
A short protein fragment that interferes with HIV, the virus that causes AIDS; studied as a potential antiviral treatment, experimental, not yet an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
SYNTHESIZED — literature evidence
Literature-extracted sequence peptide — synthesized for bioassay as documented in linked reference(s)
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BIOASSAYED — literature evidence
Activity measured in linked reference(s) — IC50/MIC/cytotoxicity data
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prediction metrics
ipTM0.000
pTM0.352
avg pLDDT56.2
ranking score0.520
STRUCTURE · PEP-05443 × ANTIMICROBIAL
ranking0.520
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530354044
ESVVINCTRPN NNTRRRLSIGP GRAFYARRNII GDIRQAHCNIS
in the news
Prions are known for misfolding. An AI found antibiotics inside them. ANTIMICROBIAL · via ANTIMICROBIAL
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| ranking score | 0.5195708870887756 | boltz-2 |
▸3-letter notation
Glu-Ser-Val-Val-Ile-Asn-Cys-Thr-Arg-Pro-Asn-Asn-Asn-Thr-Arg-Arg-Arg-Leu-Ser-Ile-Gly-Pro-Gly-Arg-Ala-Phe-Tyr-Ala-Arg-Arg-Asn-Ile-Ile-Gly-Asp-Ile-Arg-Gln-Ala-His-Cys-Asn-Ile-Ser
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | none_monomer |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-23 |
▸citationbibtex
peptidemodel (2026). Viral envelope gp160 HIV-blocking peptide (pep-05443, v1). PeptideModel. https://peptidemodel.com/card/pep-05443
@peptide{pep05443,
sequence = {ESVVINCTRPNNNTRRRLSIGPGRAFYARRNIIGDIRQAHCNIS},
target = {antimicrobial},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
references
discussion
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