pep-05176 v1 CC-BY-SA-4.0
POMC appetite and blood-sugar peptide
A lab-stage peptide aimed at the body's appetite and blood-sugar control system; not an approved medicine and only tested in research settings.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.653
pTM0.727
avg pLDDT38.0
ranking score0.763
STRUCTURE · PEP-05176 × GLP-1R
ranking0.763
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530
EDVSAGEDCGPLPEG GPEPRSDGAKPGPRE
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6532381772994995 | openfold3-mlx |
| ranking score | 0.7634202241897583 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.783 | global PDE — lower = better |
| disorder | 0.191 | fraction disordered |
| chain pair ipTM (A, B) | 0.653 | interface quality |
▸3-letter notation
Glu-Asp-Val-Ser-Ala-Gly-Glu-Asp-Cys-Gly-Pro-Leu-Pro-Glu-Gly-Gly-Pro-Glu-Pro-Arg-Ser-Asp-Gly-Ala-Lys-Pro-Gly-Pro-Arg-Glu
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| diffusion samples | 1 |
| runtime | 421s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-16 |
python3 openfold3/run_openfold.py predict --query_json {query.json} --runner_yaml examples/example_runner_yamls/mlx_runner.yml --output_dir {output_dir} --num_diffusion_samples 1 ▸citationbibtex
peptidemodel (2026). POMC appetite and blood-sugar peptide (pep-05176, v1). PeptideModel. https://peptidemodel.com/card/pep-05176
@peptide{pep05176,
sequence = {EDVSAGEDCGPLPEGGPEPRSDGAKPGPRE},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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