pep-05060 v1 CC-BY-SA-4.0
POMC appetite and blood-sugar peptide
An experimental peptide that nudges the body's appetite and blood-sugar control system; being studied for weight and metabolic effects, not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.419
pTM0.635
avg pLDDT40.1
ranking score0.565
STRUCTURE · PEP-05060 × GLP-1R
ranking0.565
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303538
ELEGEQPDGLEQVLEPDTE KADGPYRVEHFRWGNPPKD
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.4192098379135132 | openfold3-mlx |
| ranking score | 0.5651480555534363 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.072 | global PDE — lower = better |
| disorder | 0.206 | fraction disordered |
| chain pair ipTM (A, B) | 0.419 | interface quality |
▸3-letter notation
Glu-Leu-Glu-Gly-Glu-Gln-Pro-Asp-Gly-Leu-Glu-Gln-Val-Leu-Glu-Pro-Asp-Thr-Glu-Lys-Ala-Asp-Gly-Pro-Tyr-Arg-Val-Glu-His-Phe-Arg-Trp-Gly-Asn-Pro-Pro-Lys-Asp
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 455s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). POMC appetite and blood-sugar peptide (pep-05060, v1). PeptideModel. https://peptidemodel.com/card/pep-05060
@peptide{pep05060,
sequence = {ELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKD},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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