pep-05074 v1 CC-BY-SA-4.0
Mating pheromone Er-20 metabolic peptide
An experimental peptide aimed at the body's blood-sugar and appetite control system, still in research, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.736
pTM0.708
avg pLDDT44.0
ranking score0.808
STRUCTURE · PEP-05074 × GLP-1R
ranking0.808
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303537
DICDDAVAQCSMTLCQLCY NTEICELSVIGSCQPPFS
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7364018559455872 | openfold3-mlx |
| ranking score | 0.8076416850090027 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.793 | global PDE — lower = better |
| disorder | 0.154 | fraction disordered |
| chain pair ipTM (A, B) | 0.736 | interface quality |
▸3-letter notation
Asp-Ile-Cys-Asp-Asp-Ala-Val-Ala-Gln-Cys-Ser-Met-Thr-Leu-Cys-Gln-Leu-Cys-Tyr-Asn-Thr-Glu-Ile-Cys-Glu-Leu-Ser-Val-Ile-Gly-Ser-Cys-Gln-Pro-Pro-Phe-Ser
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 1845s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Mating pheromone Er-20 metabolic peptide (pep-05074, v1). PeptideModel. https://peptidemodel.com/card/pep-05074
@peptide{pep05074,
sequence = {DICDDAVAQCSMTLCQLCYNTEICELSVIGSCQPPFS},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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