pep-10522 v1 CC-BY-SA-4.0
Melanin-concentrating hormone (MCH): natural hunger and metabolism signal
A natural hormone found in humans, mice, and rats that helps regulate appetite, energy balance, and sexual function; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.920
pTM0.877
avg pLDDT81.3
ranking score0.834
STRUCTURE · PEP-10522 × MC4R
ranking0.834
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101519
DFDMLRCMLGRVYRPCWQV
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.9195854067802429 | boltz-2 |
| ranking score | 0.8342164158821106 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.804 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). Melanin-concentrating hormone (MCH): natural hunger and metabolism signal (pep-10522, v1). PeptideModel. https://peptidemodel.com/card/pep-10522
@peptide{pep10522,
sequence = {DFDMLRCMLGRVYRPCWQV},
target = {mc4r},
author = {peptidemodel},
year = {2026},
status = {synthesized}
} clinical trials
ct.gov trials
2
PubMed reviews 1
by phase
2no phase
by status
1terminated1unknown
references
discussion
sign in to comment