pep-10460 v1 CC-BY-SA-4.0
Nerve-signal receptor peptide (CHEMBL2111789)
A short experimental peptide that latches onto a nerve receptor involved in pain and inflammation signals; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.921
pTM0.941
avg pLDDT67.9
ranking score0.727
STRUCTURE · PEP-10460 × TACR2
ranking0.727
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
156
PGVGGW
in the news
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| Ki | 31000 nM | GPCRDB/ChEMBL |
▸3-letter notation
Pro-Gly-Val-Gly-Gly-Trp
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | colabfold_local |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-22 |
▸citationbibtex
peptidemodel (2026). Nerve-signal receptor peptide (CHEMBL2111789) (pep-10460, v1). PeptideModel. https://peptidemodel.com/card/pep-10460
@peptide{pep10460,
sequence = {PGVGGW},
target = {tacr2},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} clinical trials
0
no registered clinical trials
as of 2026-05-22; we'll re-check periodically
references
0
no peer-reviewed references
this sequence isn't grounded in any published literature.
discussion
sign in to comment