pep-10376 v1 CC-BY-SA-4.0
Hormone-blocker peptide (CHEMBL438652)
A short experimental peptide that blocks the body's hormone-release trigger; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.928
pTM0.926
avg pLDDT77.5
ranking score0.806
STRUCTURE · PEP-10376 × GNRHR
ranking0.806
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
157
HSYGLRP
in the news
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| IC50 | 6 nM | GPCRDB/ChEMBL |
▸3-letter notation
His-Ser-Tyr-Gly-Leu-Arg-Pro
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | colabfold_local |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-22 |
▸citationbibtex
peptidemodel (2026). Hormone-blocker peptide (CHEMBL438652) (pep-10376, v1). PeptideModel. https://peptidemodel.com/card/pep-10376
@peptide{pep10376,
sequence = {HSYGLRP},
target = {gnrhr},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
clinical trials
0
no registered clinical trials
as of 2026-05-22; we'll re-check periodically
references
discussion
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