pep-05455 v1 CC-BY-SA-4.0
VGF brain signaling peptide
A brain-signaling molecule that latches onto the same docking sites as opioids; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.789
pTM0.719
avg pLDDT48.9
ranking score0.893
STRUCTURE · PEP-05455 × OPRM1
ranking0.893
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101520253033
GGGEDEVGEED EEAAEAEAEAE EAERARQNALL
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7894845604896545 | openfold3-mlx |
| ranking score | 0.8930992484092712 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.759 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Gly-Gly-Gly-Glu-Asp-Glu-Val-Gly-Glu-Glu-Asp-Glu-Glu-Ala-Ala-Glu-Ala-Glu-Ala-Glu-Ala-Glu-Glu-Ala-Glu-Arg-Ala-Arg-Gln-Asn-Ala-Leu-Leu
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). VGF brain signaling peptide (pep-05455, v1). PeptideModel. https://peptidemodel.com/card/pep-05455
@peptide{pep05455,
sequence = {GGGEDEVGEEDEEAAEAEAEAEEAERARQNALL},
target = {oprm1},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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