pep-05450 v1 CC-BY-SA-4.0
Proenkephalin opioid signaling peptide
A neuropeptide, a natural chemical messenger the brain and nerves use to send signals, that latches onto opioid receptors (the same docking sites targeted by painkillers); used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
SYNTHESIZED — literature evidence
Literature-extracted sequence peptide — synthesized for bioassay as documented in linked reference(s)
Fork this card to add platform evidence →
BIOASSAYED — literature evidence
Activity measured in linked reference(s) — IC50/MIC/cytotoxicity data
Fork this card to add platform evidence →
prediction metrics
ipTM0.842
pTM0.776
avg pLDDT77.4
ranking score0.787
STRUCTURE · PEP-05450 × OPRM1
ranking0.787
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530354041
DAEEDDSLANSSDL LKELLETGDNRERS HHQDGSDNEEEVS
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.8417314887046814 | boltz-2 |
| ranking score | 0.7874081134796143 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.079 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Asp-Ala-Glu-Glu-Asp-Asp-Ser-Leu-Ala-Asn-Ser-Ser-Asp-Leu-Leu-Lys-Glu-Leu-Leu-Glu-Thr-Gly-Asp-Asn-Arg-Glu-Arg-Ser-His-His-Gln-Asp-Gly-Ser-Asp-Asn-Glu-Glu-Glu-Val-Ser
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). Proenkephalin opioid signaling peptide (pep-05450, v1). PeptideModel. https://peptidemodel.com/card/pep-05450
@peptide{pep05450,
sequence = {DAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVS},
target = {oprm1},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
references
discussion
sign in to comment