pep-05118 v1 CC-BY-SA-4.0
PYY2 blood-sugar & appetite peptide
Aims to act on the body's natural blood sugar and hunger control system, the same pathway used by drugs like Ozempic. Still experimental, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.637
pTM0.755
avg pLDDT71.8
ranking score0.702
STRUCTURE · PEP-05118 × GLP-1R
ranking0.702
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101520253033
MATVLLALLVY LGALVDAYPIK PEAPGEDAFLG
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6373433470726013 | boltz-2 |
| ranking score | 0.702225923538208 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.305 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Met-Ala-Thr-Val-Leu-Leu-Ala-Leu-Leu-Val-Tyr-Leu-Gly-Ala-Leu-Val-Asp-Ala-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Phe-Leu-Gly
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). PYY2 blood-sugar & appetite peptide (pep-05118, v1). PeptideModel. https://peptidemodel.com/card/pep-05118
@peptide{pep05118,
sequence = {MATVLLALLVYLGALVDAYPIKPEAPGEDAFLG},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
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