pep-05089 v1 CC-BY-SA-4.0
Pancreatic polypeptide blood-sugar peptide
A lab-stage peptide that nudges the body's blood-sugar and hunger control system; experimental, not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.711
pTM0.691
avg pLDDT44.8
ranking score0.774
STRUCTURE · PEP-05089 × GLP-1R
ranking0.774
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303536
GPVQPTYPGDDAPVEDLV RFYNDLQQYLNVVTRHRY
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.711148738861084 | openfold3-mlx |
| ranking score | 0.7742509841918945 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.797 | global PDE — lower = better |
| disorder | 0.134 | fraction disordered |
| chain pair ipTM (A, B) | 0.711 | interface quality |
▸3-letter notation
Gly-Pro-Val-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asp-Ala-Pro-Val-Glu-Asp-Leu-Val-Arg-Phe-Tyr-Asn-Asp-Leu-Gln-Gln-Tyr-Leu-Asn-Val-Val-Thr-Arg-His-Arg-Tyr
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 436s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Pancreatic polypeptide blood-sugar peptide (pep-05089, v1). PeptideModel. https://peptidemodel.com/card/pep-05089
@peptide{pep05089,
sequence = {GPVQPTYPGDDAPVEDLVRFYNDLQQYLNVVTRHRY},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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