pep-05063 v1 CC-BY-SA-4.0
IAPP blood-sugar and appetite peptide
Aims to switch on the body's GLP-1 pathway, the same system targeted by drugs like Ozempic, to help steady blood sugar and curb appetite. Early-stage research, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.671
pTM0.695
avg pLDDT42.5
ranking score0.739
STRUCTURE · PEP-05063 × GLP-1R
ranking0.739
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303537
KCNTATCVTQRLADFLVRS SNTIGTVYAPTNVGAAAY
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6710863709449768 | openfold3-mlx |
| ranking score | 0.7388783097267151 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.887 | global PDE — lower = better |
| disorder | 0.126 | fraction disordered |
| chain pair ipTM (A, B) | 0.671 | interface quality |
▸3-letter notation
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-Gln-Arg-Leu-Ala-Asp-Phe-Leu-Val-Arg-Ser-Ser-Asn-Thr-Ile-Gly-Thr-Val-Tyr-Ala-Pro-Thr-Asn-Val-Gly-Ala-Ala-Ala-Tyr
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 438s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). IAPP blood-sugar and appetite peptide (pep-05063, v1). PeptideModel. https://peptidemodel.com/card/pep-05063
@peptide{pep05063,
sequence = {KCNTATCVTQRLADFLVRSSNTIGTVYAPTNVGAAAY},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
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