pep-05061 v1 CC-BY-SA-4.0
Endothelin-1 blood-sugar and appetite peptide
Targets the same body switch that newer weight and diabetes drugs hit; still experimental, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.622
pTM0.700
avg pLDDT44.8
ranking score0.715
STRUCTURE · PEP-05061 × GLP-1R
ranking0.715
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303538
CSCSSLMDKECVYFCHLDI IWVNTPEHVVPYGLGSPRS
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6224344968795776 | openfold3-mlx |
| ranking score | 0.7147821187973022 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.928 | global PDE — lower = better |
| disorder | 0.154 | fraction disordered |
| chain pair ipTM (A, B) | 0.622 | interface quality |
▸3-letter notation
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 456s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Endothelin-1 blood-sugar and appetite peptide (pep-05061, v1). PeptideModel. https://peptidemodel.com/card/pep-05061
@peptide{pep05061,
sequence = {CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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