pep-05038 v1 CC-BY-SA-4.0
NPY blood-sugar peptide
A lab-made peptide that hits the same body switch as Ozempic-style diabetes and weight-loss drugs, still experimental, not approved.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.744
pTM0.683
avg pLDDT42.7
ranking score0.808
STRUCTURE · PEP-05038 × GLP-1R
ranking0.808
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303540
DNSEMLAPPPRPEEFTSAQQ LRQYLAALNEYYSIMGRPRF
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7438269853591919 | openfold3-mlx |
| ranking score | 0.8082297444343567 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.838 | global PDE — lower = better |
| disorder | 0.153 | fraction disordered |
| chain pair ipTM (A, B) | 0.744 | interface quality |
▸3-letter notation
Asp-Asn-Ser-Glu-Met-Leu-Ala-Pro-Pro-Pro-Arg-Pro-Glu-Glu-Phe-Thr-Ser-Ala-Gln-Gln-Leu-Arg-Gln-Tyr-Leu-Ala-Ala-Leu-Asn-Glu-Tyr-Tyr-Ser-Ile-Met-Gly-Arg-Pro-Arg-Phe
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| runtime | 467s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). NPY blood-sugar peptide (pep-05038, v1). PeptideModel. https://peptidemodel.com/card/pep-05038
@peptide{pep05038,
sequence = {DNSEMLAPPPRPEEFTSAQQLRQYLAALNEYYSIMGRPRF},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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