pep-05036 v1 CC-BY-SA-4.0
PalI metabolic peptide
Acts on the body's blood-sugar and appetite control switch; still in research, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.732
pTM0.739
avg pLDDT40.7
ranking score0.836
STRUCTURE · PEP-05036 × GLP-1R
ranking0.836
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303540
LVPRGSRAGSPSGGPFCALA RQPLTGARLMSGLFFALHET
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7323184609413147 | openfold3-mlx |
| ranking score | 0.8360612988471985 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.753 | global PDE — lower = better |
| disorder | 0.205 | fraction disordered |
| chain pair ipTM (A, B) | 0.732 | interface quality |
▸3-letter notation
Leu-Val-Pro-Arg-Gly-Ser-Arg-Ala-Gly-Ser-Pro-Ser-Gly-Gly-Pro-Phe-Cys-Ala-Leu-Ala-Arg-Gln-Pro-Leu-Thr-Gly-Ala-Arg-Leu-Met-Ser-Gly-Leu-Phe-Phe-Ala-Leu-His-Glu-Thr
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| runtime | 539s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). PalI metabolic peptide (pep-05036, v1). PeptideModel. https://peptidemodel.com/card/pep-05036
@peptide{pep05036,
sequence = {LVPRGSRAGSPSGGPFCALARQPLTGARLMSGLFFALHET},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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