pep-05023 v1 CC-BY-SA-4.0
Chromogranin-A blood-sugar and weight peptide
Hits the same body target as today's diabetes and weight-loss shots, but it's still a lab experiment, not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.555
pTM0.686
avg pLDDT41.3
ranking score0.678
STRUCTURE · PEP-05023 × GLP-1R
ranking0.678
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530354044
GYPEEKKEEEG SANRRPEDQEL ESLSAIEAELE KVAHQLQALRR
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.5551124215126038 | openfold3-mlx |
| ranking score | 0.6780247092247009 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.938 | global PDE — lower = better |
| disorder | 0.193 | fraction disordered |
| chain pair ipTM (A, B) | 0.555 | interface quality |
▸3-letter notation
Gly-Tyr-Pro-Glu-Glu-Lys-Lys-Glu-Glu-Glu-Gly-Ser-Ala-Asn-Arg-Arg-Pro-Glu-Asp-Gln-Glu-Leu-Glu-Ser-Leu-Ser-Ala-Ile-Glu-Ala-Glu-Leu-Glu-Lys-Val-Ala-His-Gln-Leu-Gln-Ala-Leu-Arg-Arg
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| runtime | 479s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Chromogranin-A blood-sugar and weight peptide (pep-05023, v1). PeptideModel. https://peptidemodel.com/card/pep-05023
@peptide{pep05023,
sequence = {GYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQALRR},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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