pep-05020 v1 CC-BY-SA-4.0
Esculentin-1 GLP-1 receptor metabolic peptide
An experimental peptide that activates the body's blood-sugar and appetite-regulating system; studied as a possible diabetes or weight-management treatment, not yet an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.618
pTM0.695
avg pLDDT42.8
ranking score0.712
STRUCTURE · PEP-05020 × GLP-1R
ranking0.712
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101520253035404546
GIFSKFGRKKIKNLLI SGLKNVGKEVGMDVVR TGIDIAGCKIKGEC
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6184626221656799 | openfold3-mlx |
| ranking score | 0.712263286113739 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.901 | global PDE — lower = better |
| disorder | 0.157 | fraction disordered |
| chain pair ipTM (A, B) | 0.618 | interface quality |
▸3-letter notation
Gly-Ile-Phe-Ser-Lys-Phe-Gly-Arg-Lys-Lys-Ile-Lys-Asn-Leu-Leu-Ile-Ser-Gly-Leu-Lys-Asn-Val-Gly-Lys-Glu-Val-Gly-Met-Asp-Val-Val-Arg-Thr-Gly-Ile-Asp-Ile-Ala-Gly-Cys-Lys-Ile-Lys-Gly-Glu-Cys
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| runtime | 524s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Esculentin-1 GLP-1 receptor metabolic peptide (pep-05020, v1). PeptideModel. https://peptidemodel.com/card/pep-05020
@peptide{pep05020,
sequence = {GIFSKFGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
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