pep-05001 v1 CC-BY-SA-4.0
Thymopoietin blood-sugar peptide
An experimental peptide that mimics a gut hormone to help control blood sugar and appetite, not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.519
pTM0.575
avg pLDDT41.4
ranking score0.589
STRUCTURE · PEP-05001 × GLP-1R
ranking0.589
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101520253035404549
PEFLEDP SVLTKEK LKSELVA NNVTLPA GEQRKDV YVELYLQ SLTALKR
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.5189231634140015 | openfold3-mlx |
| ranking score | 0.5886729955673218 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.120 | global PDE — lower = better |
| disorder | 0.117 | fraction disordered |
| chain pair ipTM (A, B) | 0.519 | interface quality |
▸3-letter notation
Pro-Glu-Phe-Leu-Glu-Asp-Pro-Ser-Val-Leu-Thr-Lys-Glu-Lys-Leu-Lys-Ser-Glu-Leu-Val-Ala-Asn-Asn-Val-Thr-Leu-Pro-Ala-Gly-Glu-Gln-Arg-Lys-Asp-Val-Tyr-Val-Glu-Leu-Tyr-Leu-Gln-Ser-Leu-Thr-Ala-Leu-Lys-Arg
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 501s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Thymopoietin blood-sugar peptide (pep-05001, v1). PeptideModel. https://peptidemodel.com/card/pep-05001
@peptide{pep05001,
sequence = {PEFLEDPSVLTKEKLKSELVANNVTLPAGEQRKDVYVELYLQSLTALKR},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
references
discussion
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