pep-04996 v1 CC-BY-SA-4.0
Insulin-1 appetite and blood sugar peptide
An early-stage peptide that acts on the body's hunger and blood-sugar control system, the same pathway used by modern weight-loss and diabetes drugs. Not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.725
pTM0.685
avg pLDDT41.3
ranking score0.781
STRUCTURE · PEP-04996 × GLP-1R
ranking0.781
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303540455051
MAPPQHLCGSHLVDALY LVCGDRGFFYNPKGIVE QCCHRPCDIFDLQSYCN
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7245399355888367 | openfold3-mlx |
| ranking score | 0.7808024883270264 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.843 | global PDE — lower = better |
| disorder | 0.128 | fraction disordered |
| chain pair ipTM (A, B) | 0.725 | interface quality |
▸3-letter notation
Met-Ala-Pro-Pro-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Asp-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Asp-Arg-Gly-Phe-Phe-Tyr-Asn-Pro-Lys-Gly-Ile-Val-Glu-Gln-Cys-Cys-His-Arg-Pro-Cys-Asp-Ile-Phe-Asp-Leu-Gln-Ser-Tyr-Cys-Asn
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | — |
| hardware | — |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | — |
| diffusion samples | 1 |
| runtime | 521s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-14 |
▸citationbibtex
peptidemodel (2026). Insulin-1 appetite and blood sugar peptide (pep-04996, v1). PeptideModel. https://peptidemodel.com/card/pep-04996
@peptide{pep04996,
sequence = {MAPPQHLCGSHLVDALYLVCGDRGFFYNPKGIVEQCCHRPCDIFDLQSYCN},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
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