pep-04992 v1 CC-BY-SA-4.0
Somatostatin-2 blood-sugar & appetite peptide
An experimental peptide that switches on the body's GLP-1 system, the same pathway behind drugs that help control blood sugar and curb appetite. Not an approved medicine.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.668
pTM0.783
avg pLDDT68.6
ranking score0.682
STRUCTURE · PEP-04992 × GLP-1R
ranking0.682
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202530354045505557
GRSHMVLNSALEGARGGPG GEEIPERFSIPELQWMLSN AELAPVQADEPPQSRMDLV
in the news
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.6681180596351624 | boltz-2 |
| ranking score | 0.6823363900184631 | boltz-2 |
▸3-letter notation
Gly-Arg-Ser-His-Met-Val-Leu-Asn-Ser-Ala-Leu-Glu-Gly-Ala-Arg-Gly-Gly-Pro-Gly-Gly-Glu-Glu-Ile-Pro-Glu-Arg-Phe-Ser-Ile-Pro-Glu-Leu-Gln-Trp-Met-Leu-Ser-Asn-Ala-Glu-Leu-Ala-Pro-Val-Gln-Ala-Asp-Glu-Pro-Pro-Gln-Ser-Arg-Met-Asp-Leu-Val
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | colabfold_nvidia |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-25 |
▸citationbibtex
peptidemodel (2026). Somatostatin-2 blood-sugar & appetite peptide (pep-04992, v1). PeptideModel. https://peptidemodel.com/card/pep-04992
@peptide{pep04992,
sequence = {GRSHMVLNSALEGARGGPGGEEIPERFSIPELQWMLSNAELAPVQADEPPQSRMDLV},
target = {glp-1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} references
discussion
sign in to comment