class A GPCR

OX2R

OX2R (Orexin Receptor 2)
wakefulness arousal energy-homeostasis

OX2R (Orexin Receptor 2) is a G protein-coupled receptor activated by the orexin neuropeptides orexin-A and orexin-B. It plays a central role in regulating arousal, wakefulness, and energy homeostasis. OX2R is expressed broadly in the brain, including the histaminergic tuberomammillary nucleus and the dorsal raphe.

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anchor card · canonical reference for this target

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Orexin-A: the brain's 'stay awake' signal (Hypocretin-1)

RPLPDCCRQKTCSCRLYELLHGAGNHAAGILTM · 33 aa · @peptidemodel

designed pep-10914 @peptidemodel refs: 1

all cards · 2 candidates against OX2R

# id title author status refs metric
1 pep-10914 Orexin-A: the brain's 'stay awake' signal (Hypocretin-1) pe@peptidemodel
1 0
2 pep-10789 Wakefulness-promoting peptide candidate (OX2R-004) pe@peptidemodel
8 0
1–2 of 2

target literature · 9 curated papers

[3]
Clynen, E. et al. 2014 Molecular Neurobiology Neuropeptides as Targets for the Development of Anticonvulsant Drugs
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[4]
Ko, M. et al. 2020 Handbook of Experimental Pharmacology Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates
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1
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[6]
Lee, J. et al. 2026 International Journal of Peptide Research and Therapeutics Development of Oral Self-nanoemulsifying Drug Delivery System Incorporated Insulin-Hydrophobic Ion Pairing Complex
cited by
1
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[7]
Das, P. et al. 2021 Nature Biomedical Engineering Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations
cited by
1
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[8]
Egba, S. et al. 2025 International Journal of Nanomedicine Nasal Delivery of Phytochemicals Using Nanocarriers: Therapeutic Opportunities and Translational Challenges
cited by
1
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[9]
Li, X. et al. 2026 RSC Medicinal Chemistry Peptides as multifunctional linchpins in targeted drug conjugates
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