rhodopsin-like GPCR (class A) · Homo sapiens

AVPR1A

V1a receptor
vasopressin V1a receptor · UniProt P37288
cardiovascular

Vasopressin V1a receptor. Mediates vasoconstriction and platelet aggregation. Primary target for terlipressin (hepatorenal syndrome, septic shock). Gq-coupled.

browse 7 cards → upload → try → + watch target

anchor card · canonical reference for this target

anchor

Vasopressin — Diabetes insipidus, enuresis

CYFQNCPRG · 9 aa · @peptidemodel

bioassayed pep-04423 @peptidemodel refs: 3

all cards · 7 candidates against AVPR1A

# id sequence title author status refs metric
1 pep-10872 CYFQNCPRD Desmopressin dDAVP pe@peptidemodel
2 0
2 pep-10514 CYFQNCPR (Arg8,des-Gly-NH29)-Vasopressin peptide pe@peptidemodel
6 0
3 pep-10513 CYFQNCPKG (Lys8)-Vasopressin peptide pe@peptidemodel
4 0
4 pep-10300 CIQNCPG AVPR2 ligand CHEMBL1817756 (7-mer) pe@peptidemodel
1 0
5 pep-10299 CFINNCPG AVPR2 ligand CHEMBL1817752 (8-mer) pe@peptidemodel
1 0
6 pep-10298 CFIQNCPG AVPR2 ligand CHEMBL1817703 (8-mer) pe@peptidemodel
1 0
1–7 of 7

lineage families · 1 families

follistatin-df 1 cards
pep-04423 CYFQNCPRG Vasopressin — Diabetes insipidus, enuresis

target literature · 13 curated papers

[1]
Han, JuliaJung, Jae HungBakker, Caitlin J.Ebell, Mark H.Dahm, Philipp 2018 BJU International Desmopressin for treating nocturia in men
cited by
1
cards
[2]
Desborough, M.J.R.Oakland, K.A.Landoni, G.Crivellari, M.Doree, C.Estcourt, L.J. 2017 Journal of Thrombosis and Haemostasis Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials
cited by
1
cards
[4]
Clynen, E. et al. 2014 Molecular Neurobiology Neuropeptides as Targets for the Development of Anticonvulsant Drugs
cited by
1
cards
[5]
Möller, C. et al. 2007 Biochemical Journal A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8
cited by
2
cards
[7]
Robben, J. et al. 2004 Molecular Biology of the Cell Regulation of the Vasopressin V2 Receptor by Vasopressin in Polarized Renal Collecting Duct Cells
cited by
2
cards
[8]
Goel, M. et al. 2010 American Journal of Physiology-Renal Physiology Role of cAMP/PKA signaling cascade in vasopressin-induced trafficking of TRPC3 channels in principal cells of the collecting duct
cited by
1
cards
[9]
Zaoral, M. et al. 1967 Collection of Czechoslovak Chemical Communications Amino acids and peptides. LXX. Synthesis of D-Arg8- and D-Lys8-vasopressin
cited by
1
cards
[10]
Wiśniewski, K. et al. 2011 Journal of Medicinal Chemistry New, Potent, Selective, and Short-Acting Peptidic V1aReceptor Agonists
cited by
3
cards

discussion · 0 threads

No discussion threads yet.