pep-04432 v1 CC-BY-SA-4.0
15101520253032
CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP
Salmon Calcitonin — Post-menopausal osteoporosis, Paget's disease
status bioassayed target CALCR length 32 aa refs 1
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.780
pTM0.710
avg pLDDT46.2
ranking score0.866
overview
Salmon Calcitonin is an FDA-approved peptide drug (approved) for Post-menopausal osteoporosis, Paget's disease. Target: Calcitonin receptor.
This is a reference scaffold — fork it for computational validation.
STRUCTURE · PEP-04432 × CALCR
ranking0.866
target interface 4.5Å peptide drag rotate · scroll zoom · right-click pan
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7797819972038269 | openfold3-mlx |
| ranking score | 0.865595817565918 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.799 | global PDE — lower = better |
| disorder | 0.200 | fraction disordered |
| chain pair ipTM (A, B) | 0.780 | interface quality |
▸3-letter notation
Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| diffusion samples | 1 |
| runtime | 456s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-25 |
python3 openfold3/run_openfold.py predict --query_json {query.json} --runner_yaml examples/example_runner_yamls/mlx_runner.yml --output_dir {output_dir} --num_diffusion_samples 1 ▸citationbibtex
peptidemodel (2026). Salmon Calcitonin — Post-menopausal osteoporosis, Paget's disease (pep-04432, v1). PeptideModel. https://peptidemodel.com/card/pep-04432
@peptide{pep04432,
sequence = {CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP},
target = {calcr},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} references
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