pep-10672 v1 CC-BY-SA-4.0
hCG hormone-blocker peptide (Chorionic Gonadotropin-β 109-145)
A lab-made fragment of the pregnancy hormone hCG that binds to the LH/hCG receptor and blocks it from being activated; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.211
pTM0.471
avg pLDDT70.1
ranking score0.603
STRUCTURE · PEP-10672 × LHCGR
ranking0.603
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
1510152025303537
TCDDPRFQDSSSSKAPPPS LPSPSRLPGPSDTPILPQ
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.2111259251832962 | boltz-2 |
| ranking score | 0.6032050251960754 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.588 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Thr-Cys-Asp-Asp-Pro-Arg-Phe-Gln-Asp-Ser-Ser-Ser-Ser-Lys-Ala-Pro-Pro-Pro-Ser-Leu-Pro-Ser-Pro-Ser-Arg-Leu-Pro-Gly-Pro-Ser-Asp-Thr-Pro-Ile-Leu-Pro-Gln
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). hCG hormone-blocker peptide (Chorionic Gonadotropin-β 109-145) (pep-10672, v1). PeptideModel. https://peptidemodel.com/card/pep-10672
@peptide{pep10672,
sequence = {TCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ},
target = {lhcgr},
author = {peptidemodel},
year = {2026},
status = {synthesized}
} related peptides
clinical trials
ct.gov trials
20
with results 6
EUCTR 6
PubMed reviews 1
by phase
1phase 12phase 23phase 33phase 43no phase
by status
6completed2not yet recruiting2unknown
top trials
NCT03353883 Early Preparation With Gonadotropin- Releasing Hormon (GnRh) Agonists Injection NCT07269392 Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo T NCT03401060 Interest of Denosumab Treatment in Osteoporosis Associated to Systemic Mastocyto NCT01976728 LutrePulse Hypogonadotropic Hypogonadism NCT02554279 MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single
references
discussion
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