pep-10528 v1 CC-BY-SA-4.0
Stress-circuit signaling peptide (PACAP Related Peptide 1-29, rat)
A natural brain peptide that switches on a stress-response receptor linked to fear, PTSD-like responses, and migraine; used only as a lab research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.783
pTM0.675
avg pLDDT38.3
ranking score0.860
STRUCTURE · PEP-10528 × PAC1R
ranking0.860
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151015202529
DVAHEILNEAYRKVL DQLSARKYLQSMVA
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.7832133769989014 | openfold3-mlx |
| ranking score | 0.8601887822151184 | openfold3-mlx |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.860 | global PDE — lower = better |
| disorder | 0.197 | fraction disordered |
| chain pair ipTM (A, B) | 0.783 | interface quality |
▸3-letter notation
Asp-Val-Ala-His-Glu-Ile-Leu-Asn-Glu-Ala-Tyr-Arg-Lys-Val-Leu-Asp-Gln-Leu-Ser-Ala-Arg-Lys-Tyr-Leu-Gln-Ser-Met-Val-Ala
▸recipeopenfold3-mlx 0.3.1
| parameter | value |
|---|---|
| model | openfold3-mlx 0.3.1 |
| weights | aedd8f3eb814e392… |
| hardware | apple_m4_base_16gb |
| mlx version | 0.31.1 |
| python | 3.14.3 |
| random seed | 42 |
| msa strategy | colabfold |
| diffusion samples | 1 |
| runtime | 432s |
| predicted by | mlx@peptide |
| predicted at | 2026-04-23 |
python3 openfold3/run_openfold.py predict --query_json {query.json} --runner_yaml examples/example_runner_yamls/mlx_runner.yml --output_dir {output_dir} --num_diffusion_samples 1 ▸citationbibtex
peptidemodel (2026). Stress-circuit signaling peptide (PACAP Related Peptide 1-29, rat) (pep-10528, v1). PeptideModel. https://peptidemodel.com/card/pep-10528
@peptide{pep10528,
sequence = {DVAHEILNEAYRKVLDQLSARKYLQSMVA},
target = {pac1r},
author = {peptidemodel},
year = {2026},
status = {computed}
} related peptides
clinical trials
ct.gov trials
18
EUCTR 2
PubMed reviews 1
by phase
2phase 11phase 47no phase
by status
3completed2recruiting1active1terminated3unknown
top trials
NCT06426316 The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology. NCT04218539 Repeat Dosing of Psilocybin in Migraine Headache NCT05857761 GAIN Symptoms: Post-traumatic Headache NCT04452929 The Effect of Anti-calcitonin Gene-related Peptide (CGRP) Receptor Antibodies on NCT03806985 Effects of Psilocybin in Concussion Headache
references
[2] supporting
discussion
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