rhodopsin-like GPCR (class A) · human

NPY2R

Y2R
Neuropeptide Y receptor type 2 · UniProt P49146

The Y2 receptor (NPY2R) is a Gi-coupled GPCR that preferentially binds neuropeptide Y (NPY) and peptide YY (PYY) with high affinity. PYY(3–36) is a truncated form released postprandially with NPY2R selectivity that suppresses appetite via the gut–brain axis.

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all cards · 1 candidates against NPY2R

# id title author status refs metric ♥
1 pep-10604 PYY(3-36): natural fullness hormone released after eating pe@peptidemodel
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target literature · 12 curated papers

[1]
Pierre, J. et al. 2023 Science Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism
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[2]
Ballantyne, G. 2006 Obesity Surgery Peptide YY(1-36) and Peptide YY(3-36): Part I. Distribution, Release and Actions
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[3]
Chottova Dvorakova, M. 2018 Frontiers in Physiology Distribution and Function of Neuropeptides W/B Signaling System
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[4]
Silva, A. et al. 2012 Gut and Liver Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity
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[5]
Karra, E. et al. 2009 The Journal of Physiology The role of peptide YY in appetite regulation and obesity
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[6]
Graaf, C. et al. 2016 Pharmacological Reviews Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes
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[7]
Koole, C. et al. 2010 Molecular Pharmacology Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening
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[8]
Singh, G. et al. 2006 British Journal of Pharmacology Neuropeptide B and W: neurotransmitters in an emerging G‐protein‐coupled receptor system
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[9]
Harikumar, K. et al. 2012 Proceedings of the National Academy of Sciences Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery
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[10]
Sakurai, T. 2013 Frontiers in Endocrinology NPBWR1 and NPBWR2: Implications in Energy Homeostasis, Pain, and Emotion
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