rhodopsin-like GPCR (class A) · human

GPR173

SREB3
G-protein-coupled receptor 173 · UniProt Q9NSA0 · gene GPR173

A poorly characterized class A GPCR expressed in the hypothalamus and pituitary with an unidentified endogenous ligand as of 2025. Orphan receptor research suggests roles in reproductive neuroendocrinology, but no selective tool compounds or clinical programs exist yet. Used for: early-stage orphan GPCR research.

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anchor card · canonical reference for this target

anchor

Phoenixin-20: brain peptide that drives reproductive hormones

DVQPPGLKVWSDPFGKSVPD · 20 aa · @peptidemodel

bioassayed pep-04483 @peptidemodel refs: 3

all cards · 1 candidates against GPR173

# id title author status refs ipSAE_d0chn
1 pep-04483 Phoenixin-20: brain peptide that drives reproductive hormones pe@peptidemodel
3 0
1–1 of 1

target literature · 3 curated papers

[1]
Yosten GLLyu RMHsueh AJHwang JISeong JYKwon OBSamson WK 2013 Journal of Neuroendocrinology A novel reproductive peptide, phoenixin
cited by
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[2]
Lyu RMHuang XFZhang YDun SLLuo JJChang JKDun NJ 2013 Neuroscience Phoenixin: a novel peptide in rodent sensory ganglia
cited by
1
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[3]
Valsamakis GArapaki ABalafoutas DCharmandari EMastorakos G 2021 Nutrients Diet-induced hypothalamic inflammation, phoenixin, and subsequent precocious puberty
cited by
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