CATEGORY · MULTI-MECHANISM

Cosmeceutical

skin

Peptides used in dermatological applications for wrinkle reduction and skin rejuvenation. Primarily target SNAP-25 to inhibit neurotransmitter release at the neuromuscular junction.

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What is a category target?

Groups peptides by what they do, not what they bind. There's no PDB or UniProt — the target is a function, not a molecule. For receptor-level structure, open a molecular target like GHSR.

anchor card · canonical reference for this target

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Argireline: topical anti-wrinkle cosmetic peptide (acetyl hexapeptide-3)

EEMQRR · 6 aa · @peptidemodel

bioassayed pep-00014 @peptidemodel refs: 2

all cards · 6 candidates against Cosmeceutical

# id title author status refs metric
1 pep-10770 Syn-Coll: skin-firming cosmetic peptide (Palmitoyl Tripeptide-5) pe@peptidemodel
7 0
2 pep-10769 Matrixyl: anti-wrinkle cosmetic peptide (Palmitoyl Pentapeptide-4, Pal-KTTKS) pe@peptidemodel
13 0
3 pep-10768 Hexapeptide-11 (Peptamide-6): yeast-derived skin peptide for cosmetics pe@peptidemodel
12 0
4 pep-10765 Anti-wrinkle face cream ingredient (SNAP-8 / Acetyl Glutamyl Heptapeptide-3) pe@peptidemodel
11 0
5 pep-00009 GHK: natural skin-repair peptide (copper-binding, found in human blood) pe@peptidemodel
3 0
6 pep-00014 Argireline: topical anti-wrinkle cosmetic peptide (acetyl hexapeptide-3) pe@peptidemodel
2 0
1–6 of 6

target literature · 46 curated papers

[1]
Robertson, I. et al. 2016 Cold Spring Harbor Perspectives in Biology Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
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[3]
Miyazono, K. et al. 2018 Frontiers of Medicine Intracellular and extracellular TGF-β signaling in cancer: some recent topics
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1
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[4]
Höppner, J. et al. 2025 Nature Communications Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation
cited by
2
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[5]
Martinez-Hackert, E. et al. 2021 Cytokine & Growth Factor Reviews Receptor binding competition: A paradigm for regulating TGF-β family action
cited by
1
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[6]
Tzavlaki, K. et al. 2020 Biomolecules TGF-β Signaling
cited by
1
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[7]
Schultz-Cherry, S. et al. 1994 Journal of Biological Chemistry The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.
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1
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[10]
Chu-Kung, A. et al. 2004 Bioconjugate Chemistry Promotion of Peptide Antimicrobial Activity by Fatty Acid Conjugation
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1
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