pep-10623 v1 CC-BY-SA-4.0
Gut hormone fragment (GRP 14-27): blocks the gut's fullness signal
A lab-made piece of a natural gut hormone that blocks the receptor controlling gallbladder squeezing and the feeling of fullness after eating; used only as a research tool.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.915
pTM0.813
avg pLDDT74.6
ranking score0.780
STRUCTURE · PEP-10623 × CCKAR
ranking0.780
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151014
MYPRGNHWAVGHLM
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.9149946570396423 | boltz-2 |
| ranking score | 0.7797093987464905 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 1.129 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). Gut hormone fragment (GRP 14-27): blocks the gut's fullness signal (pep-10623, v1). PeptideModel. https://peptidemodel.com/card/pep-10623
@peptide{pep10623,
sequence = {MYPRGNHWAVGHLM},
target = {cckar},
author = {peptidemodel},
year = {2026},
status = {synthesized}
} related peptides
clinical trials
ct.gov trials
32
with results 5
PubMed reviews 4
by phase
2phase 15phase 21early phase 13no phase
by status
5completed1recruiting1active1terminated1unknown
top trials
NCT03889210 β-hydroxybutyrate, Glucose Metabolism and Prediabetes NCT02653859 Evaluate the Auxiliary Diagnostic Value of Circulating Tumor Cells in Benign and NCT06379217 NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR T NCT01748565 Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia NCT03113617 68Ga-RM2 PET/CT in Detecting Regional Nodal and Distant Metastases in Patients W
references
discussion
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