Secretin (rat version): gut hormone that aids digestion
A rat form of secretin, a natural gut hormone that signals the pancreas to release digestive juices; used only as a lab research tool.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
A second contributor repeated the computation on their own hardware and the scores matched.
Named peptide fragment — synthesized for research; ClinicalTrials.gov trials registered for parent compound or class
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Endogenous peptide fragment — receptor binding/activity established in published literature; CT.gov evidence
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Research directions for this peptide, selected from the current sources — hypotheses you can explore and model. None of it is proven yet; tap any one to see the full thinking.
Could rat secretin, beyond helping digestion, also slow down the scarring process that damages the pancreas in chronic pancreatitis?
Chronic pancreatitis causes irreversible damage and has no approved anti-scarring treatment. If secretin can calm the cells that drive this scarring, it could be repurposed as the first disease-modifying therapy for this painful and debilitating condition.
If you shorten rat secretin by cutting its hydrophobic tail, does it stop activating the receptor and instead block it?
If true, a shortened version of secretin could act as a blocker rather than an activator of the secretin receptor. This could help researchers study diseases linked to secretin overactivity and might lead to new drugs.
Does the floppy middle section of rat secretin actually help it bind its receptor by giving it more freedom of movement?
Understanding why the middle of secretin stays flexible could explain why this peptide hormone works well in the body. It might guide scientists designing new gut hormone drugs that are harder for the body to break down.
Could a stable form of rat secretin act on receptors in the brain's memory center to spur new nerve cells and ease anxiety, separate from any autism link?
If secretin acts on the brain's memory center, it might point toward uses for anxiety or memory disorders, not just digestive conditions. This would suggest a new direction for a peptide whose autism trials gave mixed results.
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.9200921654701233 | boltz-2 |
| ranking score | 0.6828665733337402 | boltz-2 |
▸3-letter notation
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | colabfold_local |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-22 |
▸citationbibtex
@peptide{pep10590,
sequence = {HSDGTFTSELSRLQDSARLQRLLQGLV},
target = {sctr},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
}