pep-10333 v1 CC-BY-SA-4.0
Brain-calming peptide (CHEMBL508083)
A small lab-made peptide that switches on a brain receptor involved in mood, pain, and appetite; experimental, not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
The peptide was actually made in a lab.
A chemistry service or a researcher ordered the sequence, it was manufactured, and mass spectrometry confirmed the right molecule was produced.
The peptide was tested on its target in a lab.
A binding or activity measurement confirmed that it actually does what the computer predicted — or didn't.
prediction metrics
ipTM0.916
pTM0.901
avg pLDDT78.6
ranking score0.812
STRUCTURE · PEP-10333 × GALR1
ranking0.812
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
15101516
GWTLNSAGYLLGPHAV
details
▸full evidence table1 metrics
| metric | value | tool |
|---|---|---|
| Ki | 0.5 nM | GPCRDB/ChEMBL |
▸3-letter notation
Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val
▸recipeboltz-2 2.2.1
| parameter | value |
|---|---|
| model | boltz-2 2.2.1 |
| weights | — |
| hardware | vast_v100_32gb |
| mlx version | — |
| python | — |
| random seed | 1 |
| msa strategy | colabfold_local |
| runtime | — |
| predicted by | — |
| predicted at | 2026-05-22 |
▸citationbibtex
peptidemodel (2026). Brain-calming peptide (CHEMBL508083) (pep-10333, v1). PeptideModel. https://peptidemodel.com/card/pep-10333
@peptide{pep10333,
sequence = {GWTLNSAGYLLGPHAV},
target = {galr1},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
pep-10335 Lab peptide that targets brain galanin receptor… same family ·same target ·5 shared papers
pep-10332 Brain-signaling blocker for pain and dementia r… same family ·same target ·3 shared papers
clinical trials
0
no registered clinical trials
as of 2026-05-22; we'll re-check periodically
references
[1] evidence
[2] evidence
[4] supporting
discussion
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