pep-04577 v1 CC-BY-SA-4.0
κ-casein blood-pressure peptide
An experimental small peptide that blocks ACE, the enzyme that tightens blood vessels and raises blood pressure, so it may help lower it. Not an approved drug.
status
Someone proposed this peptide.
A researcher, an agent, or an algorithm wrote down the sequence and picked a target to hit.
A computer predicted how the peptide binds to its target.
An AI model like OpenFold3 or AlphaFold built a 3D structure and scored how well it fits the binding site.
Someone else ran the same prediction and got the same result.
A second contributor repeated the computation on their own hardware and the scores matched.
SYNTHESIZED — literature evidence
Literature-extracted sequence peptide — synthesized for bioassay as documented in linked reference(s)
Fork this card to add platform evidence →
BIOASSAYED — literature evidence
Activity measured in linked reference(s) — IC50/MIC/cytotoxicity data
Fork this card to add platform evidence →
prediction metrics
ipTM0.831
pTM0.604
avg pLDDT89.8
ranking score0.885
STRUCTURE · PEP-04577 × ACE
ranking0.885
target interface 4.5Å peptide drag rotate · ctrl+scroll zoom · right-click pan
sequence
151012
FSDKIAKYIPIQ
details
▸full evidence table2 metrics
| metric | value | tool |
|---|---|---|
| ipTM | 0.8313287496566772 | boltz-2 |
| ranking score | 0.8846535086631775 | boltz-2 |
▸structural qualityopenfold3
| metric | value | note |
|---|---|---|
| gpde | 0.955 | global PDE — lower = better |
| disorder | NaN | fraction disordered |
▸3-letter notation
Phe-Ser-Asp-Lys-Ile-Ala-Lys-Tyr-Ile-Pro-Ile-Gln
▸recipeboltz-2 1.0
| parameter | value |
|---|---|
| model | boltz-2 1.0 |
| weights | — |
| hardware | nvidia_nim_api |
| mlx version | — |
| python | — |
| random seed | — |
| msa strategy | none |
| diffusion samples | 1 |
| runtime | — |
| predicted by | mlx@peptide |
| predicted at | 2026-04-24 |
▸citationbibtex
peptidemodel (2026). κ-casein blood-pressure peptide (pep-04577, v1). PeptideModel. https://peptidemodel.com/card/pep-04577
@peptide{pep04577,
sequence = {FSDKIAKYIPIQ},
target = {ace},
author = {peptidemodel},
year = {2026},
status = {bioassayed}
} related peptides
references
discussion
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